Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.

Titel:: Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.
Dokumenttyp:: Case Reports
Autor(en):: Wylezich, Claudia; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk; Schlegel, Jürgen; Beer, Martin; Dintner, Sebastian
Abstract:: Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
Zeitschriftentitel:: Diagn Microbiol Infect Dis
Jahr:: 2021
Band / Volume:: 101
Heft / Issue:: 4
Volltext / DOI:: doi:10.1016/j.diagmicrobio.2021.115520
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/34536911
Print-ISSN:: 0732-8893
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie
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