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Document type:
Journal Article
Author(s):
Schmitt, Katrin; Molfenter, Britta; Koerich Laureano, Natalia; Tawk, Bouchra; Bieg, Matthias; Pastor Hostench, Xavier; Weichenhan, Dieter; Ullrich, Nina D; Shang, Viny; Richter, Daniela; Stögbauer, Fabian; Schroeder, Lea; de Bem Prunes, Bianca; Visioli, Fernanda; Varvaki Rados, Pantelis; Jou, Adriana; Plath, Michaela; Federspil, Philippe A; Thierauf, Julia; Döscher, Johannes; Weissinger, Stephanie E; Hoffmann, Thomas K; Wagner, Steffen; Wittekindt, Claus; Ishaque, Naveed; Eils, Roland; Klussmann...     »
Title:
Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.
Abstract:
Genomic sequencing projects unraveled the mutational landscape of head and neck squamous cell carcinoma (HNSCC) and provided a comprehensive catalog of somatic mutations. However, the limited number of significant cancer-related genes obtained so far only partially explains the biological complexity of HNSCC and hampers the development of novel diagnostic biomarkers and therapeutic targets. We pursued a multiscale omics approach based on whole-exome sequencing, global DNA methylation and gene ex...     »
Journal title abbreviation:
Int J Cancer
Year:
2019
Journal volume:
145
Journal issue:
12
Pages contribution:
3299-3310
Fulltext / DOI:
doi:10.1002/ijc.32481
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31135957
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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