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- Original title:
- Immunmodulation durch CXC-Chemokine beim kolorektalen Karzinom
- Translated title:
- CXC-Chemokines as crucial immune mediators in colorectal carcinogenesis
- Author:
- Kistner, Larissa Renate
- Year:
- 2015
- Document type:
- Dissertation
- Faculty/School:
- Fakultät Wissenschaftszentrum Weihenstephan
- Advisor:
- Haller, Dirk (Prof. Dr.)
- Referee:
- Haller, Dirk (Prof. Dr.); Janssen, Klaus-Peter (Priv.-Doz. Dr.)
- Language:
- de
- Subject group:
- BIO Biowissenschaften; MED Medizin
- Keywords:
- CXC-Chemokine, CXCL9, CXCL10, CXCL11, kolorektales Karzinom, Immunmodulation, Immunsystem, Tumor
- Translated keywords:
- CXC-chemokines, CXCL9, CXCL10, CXCL11, colorectal carcinoma, immune mediators, immune system, tumor
- Abstract:
- Tumormikromilieu und Immunsystem beeinflussen die Tumorentwicklung maßgeblich. Die Analyse humaner Kolorekaktalkarzinome ergab eine große prognostische Bedeutung für Interferon-induzierbare CXC-Chemokine (lösliche Immunmediatoren). Tumorzellen stellen die Hauptproduzenten dieser CXC-Chemokine dar. In einem orthotopen Mausmodell für Rektalkarzinome konnte ein protektiver Effekt der Ausprägung von CXCL10 nachgewiesen werden, vermittelt über das adaptive Immunsystem und die Hemmung der Angiogenese.
- Translated abstract:
- Tumorigenesis is influenced by the tumor microenvironment and the immune system. Interferon-induced CXCL-chemokines, soluble immune mediators, were identified as crucial indicators for good prognosis in patients with colon cancer. Cancer cells were identified as main producers of CXCs within colon tumors. An orthotopic mouse model for rectal cancer was established, demonstrating a protective anti-tumoral role for the chemokine CXCL10, mediated by adaptive immunity and inhibition of angiogenesis.
- WWW:
- https://mediatum.ub.tum.de/?id=1231087
- Date of submission:
- 06.10.2014
- Oral examination:
- 12.02.2015
- File size:
- 5174762 bytes
- Pages:
- 177
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20150212-1231087-0-4
- Last change:
- 11.03.2015
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