Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey.

Kamisawa, T; Chari, ST; Giday, SA; Kim, MH; Chung, JB; Lee, KT; Werner, J; Bergmann, F; Lerch, MM; Mayerle, J; Pickartz, T; Löhr, M; Schneider, A; Frulloni, L; Webster, GJ; Reddy, DN; Liao, WC; Wang, HP; Okazaki, K; Shimosegawa, T; Kloeppel, G; Go, VL

doi:10.1097/MPA.0b013e3182258a15

Benutzer: Gast

journal article

Titel:: Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey.
Dokumenttyp:: Journal Article
Autor(en):: Kamisawa, T; Chari, ST; Giday, SA; Kim, MH; Chung, JB; Lee, KT; Werner, J; Bergmann, F; Lerch, MM; Mayerle, J; Pickartz, T; Löhr, M; Schneider, A; Frulloni, L; Webster, GJ; Reddy, DN; Liao, WC; Wang, HP; Okazaki, K; Shimosegawa, T; Kloeppel, G; Go, VL
Abstract:: : The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world.: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients.: Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP.: Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
Zeitschriftentitel:: Pancreas
Jahr:: 2011
Band / Volume:: 40
Heft / Issue:: 6
Seitenangaben Beitrag:: 809-14
Sprache:: eng
Volltext / DOI:: doi:10.1097/MPA.0b013e3182258a15
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/21747310
Print-ISSN:: 0885-3177
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie
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