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Title:

Chlamydia trachomatis can protect host cells against apoptosis in the absence of cellular Inhibitor of Apoptosis Proteins and Mcl-1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ying, S; Christian, JG; Paschen, SA; Häcker, G
Abstract:
Infection with Chlamydia protects mammalian host cells against apoptosis. Hypotheses have been proposed to explain this molecularly, including the up-regulation of host anti-apoptotic proteins such as cellular Inhibitor of Apoptosis Protein (IAP) 2 and the Bcl-2 protein Mcl-1. To test for the importance of these proteins, we used mouse embryonic fibroblasts from gene-targeted mice that were deficient in cIAP1, cIAP2, cIAP1/cIAP2, XIAP, or Mcl-1. Infection with Chlamydia trachomatis protected all...     »
Journal title abbreviation:
Microbes Infect
Year:
2008
Journal volume:
10
Journal issue:
1
Pages contribution:
97-101
Language:
eng
Fulltext / DOI:
doi:10.1016/j.micinf.2007.10.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18069034
Print-ISSN:
1286-4579
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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