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Title:

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Herrmann, S; Stieber, J; Stöckl, G; Hofmann, F; Ludwig, A
Abstract:
Cardiac pacemaking involves a variety of ion channels, but their relative importance is controversial and remains to be determined. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, which underlie the I(f) current of sinoatrial cells, are thought to be key players in cardiac automaticity. In addition, the increase in heart rate following beta-adrenergic stimulation has been attributed to the cAMP-mediated enhancement of HCN channel activity. We have now studied mice in which t...     »
Journal title abbreviation:
EMBO J
Year:
2007
Journal volume:
26
Journal issue:
21
Pages contribution:
4423-32
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.emboj.7601868
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17914461
Print-ISSN:
0261-4189
TUM Institution:
Institut für Pharmakologie und Toxikologie
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