Unspecific parotitis can be the first indication of a developing Wegener's granulomatosis.

In an unusual course of Wegener's granulomatosis (WG), a 71-year-old woman presented a 3-week history of unilateral painful parotid swelling unresponsive to antiphlogistic and antibiotic treatment. Following lateral parotidectomy with unspecific inflammatory histopathological findings, the patient developed disturbance of wound healing and high recurrent fever. Control chest X-ray showed several pulmonary round lesions. Immunologic testing for antinuclear cytoplasmatic antibodies (ANCA) was positive and CT navigated puncture revealed pronounced necrotic vasculitis of small arteries and veins. Consequently, systemic WG was diagnosed and specific immunosuppressive therapy was started. Long-term follow-up of 6 months showed a decline in the ANCA course, full remission of the presented symptoms and prevention of renal manifestations. Isolated inflammatory parotid enlargement can be the initial symptom of systemic WG and should be considered as differential diagnosis, especially when nondiagnostic histopathological results are obtained. Early testing for c-ANCA supplies valuable information and therefore should be prompted when additional symptoms occur. Once diagnosed as WG, appropriate therapy is able to prevent progression to severe clinical courses.     «

In an unusual course of Wegener's granulomatosis (WG), a 71-year-old woman presented a 3-week history of unilateral painful parotid swelling unresponsive to antiphlogistic and antibiotic treatment. Following lateral parotidectomy with unspecific inflammatory histopathological findings, the patient developed disturbance of wound healing and high recurrent fever. Control chest X-ray showed several pulmonary round lesions. Immunologic testing for antinuclear cytoplasmatic antibodies (ANCA) was posi...     »