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- Title:
Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.
- Document type:
- Case Reports
- Author(s):
- Wylezich, Claudia; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk; Schlegel, Jürgen; Beer, Martin; Dintner, Sebastian
- Abstract:
- Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
- Journal title abbreviation:
- Diagn Microbiol Infect Dis
- Year:
- 2021
- Journal volume:
- 101
- Journal issue:
- 4
- Fulltext / DOI:
- doi:10.1016/j.diagmicrobio.2021.115520
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/34536911
- Print-ISSN:
- 0732-8893
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
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