User: Guest  Login
Title:

Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.

Document type:
Journal Article
Author(s):
Pfarr, Nicole; Allgäuer, Michael; Steiger, Katja; Weichert, Wilko; Schirmacher, Peter; Noske, Aurelia; Stenzinger, Albrecht
Abstract:
About 60-70% of hidradenoma papilliferum (HP), a benign tumour of the anogenital region, were recently described to harbour mutations in major driver genes of the PI3K/AKT/MAPK-signalling pathways. However, the underlying genetic defects of the non-mutant cases are still unknown. Using a 409 gene panel, we employed targeted next generation sequencing to investigate the mutational landscape in a cohort of seven PI3K/AKT-negative cases and five cases with known hotspot mutations in either PIK3CA o...     »
Journal title abbreviation:
Pathology
Year:
2019
Journal volume:
51
Journal issue:
4
Pages contribution:
362-368
Fulltext / DOI:
doi:10.1016/j.pathol.2019.01.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31010589
Print-ISSN:
0031-3025
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX