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Title:

Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: a post-mortem study in human control subjects.

Document type:
Journal Article
Author(s):
Lu, L; Neff, F; Fischer, DA; Henze, C; Hirsch, EC; Oertel, WH; Schlegel, J; Hartmann, A
Abstract:
Parkinson's disease (PD) is characterized by loss of dopaminergic (DA) neurons in the human midbrain, which varies greatly among mesencephalic subregions. The genetic expression profiles of mesencephalic DA neurons particularly prone to degenerate during PD (nigrosome 1 within the substantia nigra pars compacta-SNpc) and those particularly resistant in the disease course (central grey substance-CGS) were compared in five control subjects by immuno-laser capture microdissection followed by RNA ar...     »
Journal title abbreviation:
Neurobiol Dis
Year:
2006
Journal volume:
23
Journal issue:
2
Pages contribution:
409-21
Language:
eng
Fulltext / DOI:
doi:10.1016/j.nbd.2006.04.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16753304
Print-ISSN:
0969-9961
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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