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- Title:
MRI of arthritis: Comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPA.
- Document type:
- Journal Article
- Author(s):
- Simon, GH; von Vopelius-Feldt, J; Wendland, MF; Fu, Y; Piontek, G; Schlegel, J; Chen, MH; Daldrup-Link, HE
- Abstract:
- PURPOSE: To compare the ability of the ultrasmall superparamagnetic iron oxide (USPIO) SHU555C vs. gadopentetate dimeglumine (Gd-DTPA) to detect antigen-induced monoarthritis with MRI. MATERIALS AND METHODS: Twelve seven-week-old female rats with an antigen-induced monoarthritis of the right knee were randomly assigned to two groups. Animals in group I (N = 6) underwent MRI using T1-weighted gradient-echo sequences before injection and at 2, 9, 17, 25, 33, 40, 47, 55, and 63 minutes postinjection (p.i.) of Gd-DTPA on day 1, and before injection and at 3, 23, 43, and 123 minutes p.i. of SHU555C on day 2. Animals in group II (N = 6) were imaged before injection and at 3, 23, 43, and 123 minutes p.i. using identical sequences. Signal-to-noise ratios (SNRs) and relative enhancement (DeltaSI%) of arthritic and normal synovium were determined from region-of-interest (ROI) measurements in consensus reading by two experienced radiologists. Data were tested for significant differences between the two agents and between the arthritic and normal knees using a mixed-effect model and F-tests (P < 0.05). Joints were processed for histopathology as the gold standard. RESULTS: USPIO and Gd-DTPA showed significant enhancement differences (P < 0.001). USPIO provided a progressive and persistent enhancement of arthritic joints while Gd-DTPA provided an early and rapidly declining enhancement. Maximal enhancement in synovitis was 400% at 40-120 minutes p.i. of USPIO vs. 300% at two minutes p.i. of Gd-DTPA. USPIO provided a significant higher difference in enhancement between the arthritic and normal synovium than Gd-DTPA (P < 0.001). Histopathology confirmed marked inflammatory synovial changes in all arthritis-induced right knee joints and normal synovium in all left knee joints. CONCLUSION: Both USPIO and Gd-DTPA detect arthritis by positive T1-enhancement. Compared to standard Gd-DTPA, the USPIO SHU555C provides a comparable maximal T1-enhancement (at two minutes p.i for Gd-DTPA and between 43 and 123 minutes p.i. for SHU555C), but in addition it provides a prolonged T1-enhancement of synovitis and a higher difference between the relative enhancement of arthritic and normal synovium. J. Magn. Reson. Imaging 2006. (c) 2006 Wiley-Liss, Inc.
- Journal title abbreviation:
- J Magn Reson Imaging
- Year:
- 2006
- Journal volume:
- 23
- Journal issue:
- 5
- Pages contribution:
- 720-7
- Language:
- eng
- Fulltext / DOI:
- doi:10.1002/jmri.20556
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/16557494
- Print-ISSN:
- 1053-1807
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
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