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Title:

Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia.

Document type:
Journal Article; Article
Author(s):
Herhaus, Peter; Habringer, Stefan; Philipp-Abbrederis, Kathrin; Vag, Tibor; Gerngross, Carlos; Schottelius, Margret; Slotta-Huspenina, Julia; Steiger, Katja; Altmann, Torben; Weisser, Tanja; Steidle, Sabine; Schick, Markus; Jacobs, Laura; Slawska, Jolanta; Mueller-Thomas, Catharina; Verbeek, Mareike; Subklewe, Marion; Peschel, Christian; Wester, Hans-Juergen; Schwaiger, Markus; Goetze, Katharina; Keller, Ulrich
Abstract:
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. Various drugs targeting this pathway have entered clinical trials. To evaluate CXCR4 imaging in acute myeloid leukemia, we first tested CXCR4 expression in patient-derived primary blasts. Flow cytometry revealed that high blast counts in patients with acute myel...     »
Journal title abbreviation:
Haematologica
Year:
2016
Journal volume:
101
Journal issue:
8
Pages contribution:
932-40
Language:
eng
Fulltext / DOI:
doi:10.3324/haematol.2016.142976
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27175029
Print-ISSN:
0390-6078
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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