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Title:

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation.

Document type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article
Author(s):
Tinhofer, I; Budach, V; Saki, M; Konschak, R; Niehr, F; Jöhrens, K; Weichert, W; Linge, A; Lohaus, F; Krause, M; Neumann, K; Endris, V; Sak, A; Stuschke, M; Balermpas, P; Rödel, C; Avlar, M; Grosu, A L; Abdollahi, A; Debus, J; Belka, C; Pigorsch, S; Combs, S E; Mönnich, D; Zips, D; Baumann, M
Abstract:
Despite clear differences in clinical presentation and outcome, squamous cell carcinomas of the head and neck (SCCHN) arising from human papilloma virus (HPV) infection or heavy tobacco/alcohol consumption are treated equally. Next-generation sequencing is expected to reveal novel targets for more individualised treatment.Tumour specimens from 208 patients with locally advanced squamous cell carcinoma of the hypopharynx, oropharynx or oral cavity, all uniformly treated with adjuvant cisplatin-ba...     »
Journal title abbreviation:
Eur J Cancer
Year:
2016
Journal volume:
57
Pages contribution:
78-86
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ejca.2016.01.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26896955
Print-ISSN:
0959-8049
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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