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Title:

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jin, Saihong; Kim, Jeehee; Willert, Torsten; Klein-Rodewald, Tanja; Garcia-Dominguez, Mario; Mosqueira, Matias; Fink, Rainer; Esposito, Irene; Hofbauer, Lorenz C; Charnay, Patrick; Kieslinger, Matthias
Abstract:
Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted to the promoters/enhancers of muscle cell-specific genes. Thus, the specificity in myogenic transcription is poorly defined. Here we describe the transcription factor Ebf3 as a new determinant of muscle cell-specific transcription. In the absence of Ebf3 the lung does not unfold at birth, resulting...     »
Journal title abbreviation:
Nat Commun
Year:
2014
Journal volume:
5
Pages contribution:
3793
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms4793
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24786561
Print-ISSN:
2041-1723
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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