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- Title:
Correlation of monoclonal and polyclonal somatostatin receptor 5 antibodies in pancreatic neuroendocrine tumors.
- Document type:
- Journal Article
- Author(s):
- Kaemmerer, D; Lupp, A; Peter, L; Fischer, E; Schulz, S; Klöppel, G; Hommann, M
- Abstract:
- To evaluate the frequency of somatostatin-receptor 5 (SSTR 5) in pancreatic neuroendocrine tumors by using monoclonal and polyclonal antibodies.we analyzed 66 proven pancreatic neuroendocrine tumors immunohistochemically with monoclonal (clone UMB-4) and polyclonal SSTR 5-antibodies. Immunoreactive score (IRS) and DAKO-score Her2/neu were evaluated.Immunohistochemistry analysis demonstrated for the IRS a significant higher staining of all specimen using the monoclonal antibodies ( IRS SSTR5 poly vs IRS SSTR 5 mono; 20.0% vs 30.3% p < 0.001) by a correlation of 0.21; p = 0.04. For the HER2 score there was also a significant higher staining in the monoclonal group (Her2 SSTR 5 poly vs Her2 SSTR 5 mono; 21.5% vs 28.8% p < 0.001) by a correlation of 0.20; p = 0.08.Both antibodies are useful in staining of SSTR, although UMB-4 demonstrated a 10% higher SSTR 5 staining. Due to the previous underestimated expression rate of SSTR 5, current standards in diagnostics and therapy should be reconsidered. The increasing usage of long-acting pansomatostatin receptor analogues will rise the adverse effects connected to SSTR5 binding.
- Journal title abbreviation:
- Int J Clin Exp Pathol
- Year:
- 2013
- Journal volume:
- 6
- Journal issue:
- 1
- Pages contribution:
- 49-54
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/23236542
- Print-ISSN:
- 1936-2625
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
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