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Titel:

Anemia and splenomegaly in cGKI-deficient mice

Dokumenttyp:
Article
Autor(en):
Foeller, Michael; Feil, S; Ghoreschi, Kamran; Koka, Saisudha; Gerling, Andrea; Thunemann, M; Hofmann, Franz; Schuler, Beat; Vogel, Johannes; Pichler, Bernd; Kasinathan, RaviS; Nicolay, JanP; Huber, StephanM; Lang, Florian; Feil, R
Abstract:
To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the regulation of erythrocyte survival, gene-targeted mice lacking cGKI were compared with their control littermates. By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed cell volume, and hemoglobin concentration. Anemia was associated with a higher reticulocyte number and an...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2008
Band / Volume:
105
Heft / Issue:
18
Seitenangaben Beitrag:
6771-6776
Sprache:
eng
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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