Multispectral optoacoustic tomography of myocardial infarction.

Taruttis, Adrian; Wildgruber, Moritz; Kosanke, Katja; Beziere, Nicolas; Licha, Kai; Haag, Rainer; Aichler, Michaela; Walch, Axel; Rummeny, Ernst; Ntziachristos, Vasilis

doi:10.1016/j.pacs.2012.11.001

Benutzer: Gast

journal article

Titel:: Multispectral optoacoustic tomography of myocardial infarction.
Dokumenttyp:: Journal Article; Journal Article
Autor(en):: Taruttis, Adrian; Wildgruber, Moritz; Kosanke, Katja; Beziere, Nicolas; Licha, Kai; Haag, Rainer; Aichler, Michaela; Walch, Axel; Rummeny, Ernst; Ntziachristos, Vasilis
Abstract:: To investigate the feasibility of a high resolution optical imaging strategy for myocardial infarction.Near-infrared approaches to imaging cardiovascular disease enable visualization of disease-associated biological processes in vivo. However, even at the scale of small animals, the strong scattering of light prevents high resolution imaging after the first 1-2 mm of tissue, leading to degraded signal localization.Multispectral optoacoustic tomography (MSOT) was used to non-invasively image myocardial infarction (MI) in a murine model of coronary artery ligation at resolutions not possible with current deep-tissue optical imaging methods. Post-MI imaging was based on resolving the spectral absorption signature of a dendritic polyglycerol sulfate-based (dPGS) near-infrared imaging agent targeted to P- and L-selectin.In vivo imaging succeeded in detection of the agent in the injured myocardium after intravenous injection. The high anatomic resolution (<200 ?m) achieved by the described method allowed signals originating in the infarcted heart to be distinguished from uptake in adjacent regions. Histological analysis found dPGS signal in infarcted areas, originating from leukocytes and endothelial cells.MSOT imaging of myocardial infarction provides non-invasive visualization of optical contrast with a high spatial resolution that is not degraded by the scattering of light.
Zeitschriftentitel:: Photoacoustics
Jahr:: 2013
Band / Volume:: 1
Heft / Issue:: 1
Seitenangaben Beitrag:: 3-8
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.pacs.2012.11.001
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/25327410
Print-ISSN:: 2213-5979
TUM Einrichtung:: Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Weitere Lehrstühle und Professuren Preclinical Medicine Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)2013