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Original title:
Mechanistic Studies on Polyketide Biosynthesis in Pathogenic Fungi and Bacteria
Translated title:
Mechanistische Untersuchungen zur Biosynthese von Polyketiden in pathogenen Pilzen und Bakterien
Author:
Schmalhofer, Maximilian
Year:
2023
Document type:
Dissertation
Faculty/School:
TUM School of Natural Sciences
Advisor:
Groll, Michael (Prof. Dr.)
Referee:
Groll, Michael (Prof. Dr.); Brück, Thomas (Prof. Dr.); Bode, Helge B. (Prof. Dr.)
Language:
en
Subject group:
CHE Chemie
TUM classification:
CHE 800
Abstract:
Aryl polyene lipids (APELs), 1,8-dihydroxynaphthalene (DHN)-melanin, and anthraquinone (AQ) are polyketides produced by pathogenic bacteria or fungi. APELs are built by aryl polyene (APE) type II polyketide synthases (PKSs) in most Gram-negative bacteria, DHN-melanin is a virulence factor in Aspergillus fumigatus, and AQ is present in Photorhabdus laumondii. This work provides mechanistic insights into their biosynthesis on a structural level and builds the foundation for further studies and the...     »
Translated abstract:
Aryl Polyen Lipide (APELs), 1,8-Dihydroxynapthalin (DHN)-Melanin und Anthrachinon (AQ) sind Polyketide, die von pathogenen Bakterien oder Pilzen hergestellt werden. APELs werden von Aryl Polyen (APE) Typ II Polyketidsynthasen (PKSs) in den meisten gramnegativen Bakterien gebildet, DHN-Melanin ist ein Virulenzfaktor in Aspergillus fumigatus, und AQ ist in Photorhabdus laumondii vorhanden. Diese Arbeit liefert mechanistische Einblicke in ihre Biosynthese auf struktureller Ebene und bildet die Grun...     »
WWW:
https://mediatum.ub.tum.de/?id=1711116
Date of submission:
31.05.2023
Oral examination:
28.07.2023
File size:
52091606 bytes
Pages:
105
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20230728-1711116-1-6
Last change:
28.07.2024
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