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Title:

Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Descot, A; Hoffmann, R; Shaposhnikov, D; Reschke, M; Ullrich, A; Posern, G
Abstract:
We analyzed the G-actin-regulated transcriptome by gene expression analysis using previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent target genes of serum response factor (SRF), as well as additional directly regulated genes. Surprisingly, several putative antiproliferative target genes were identified, including mig6/errfi-1, a negative regulator of the EGFR family. Mig6 induction occurred through actin-MAL-SRF signaling, and MAL was inducibly recruited to and...     »
Journal title abbreviation:
Mol Cell
Year:
2009
Journal volume:
35
Journal issue:
3
Pages contribution:
291-304
Language:
eng
Fulltext / DOI:
doi:10.1016/j.molcel.2009.07.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19683494
Print-ISSN:
1097-2765
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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