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Title:

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fritsche, P; Seidler, B; Schüler, S; Schnieke, A; Göttlicher, M; Schmid, RM; Saur, D; Schneider, G
Abstract:
BACKGROUND: Although histone deacetylase inhibitors (HDACi) are promising cancer therapeutics regulating proliferation, differentiation and apoptosis, molecular pathways engaged by specific HDAC isoenzymes in cancer are ill defined. RESULTS: In this study we demonstrate that HDAC2 is highly expressed in pancreatic ductal adenocarcinoma (PDAC), especially in undifferentiated tumours. We show that HDAC2, but not HDAC1, confers resistance towards the topoisomerase II inhibitor etoposide in PDAC cel...     »
Journal title abbreviation:
Gut
Year:
2009
Journal volume:
58
Journal issue:
10
Pages contribution:
1399-409
Language:
eng
Fulltext / DOI:
doi:10.1136/gut.2009.180711
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19528037
Print-ISSN:
0017-5749
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Toxikologie und Umwelthygiene
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