Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: example of a threshold carcinogen.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Sweeney, LM; Kirman, CR; Albertini, RJ; Tan, YM; Clewell, HJ; Filser, JG; Csanady, G; Pottenger, LH; Banton, MI; Graham, CJ; Andrews, LS; Papciak, RJ; Gargas, ML
Abstract:
Propylene oxide (PO) is an important industrial chemical used primarily in the synthesis of other compounds. Inhalation carcinogenesis studies in rodents, with no-observed-adverse-effect levels (NOAELs) of 100 and 200 ppm, have revealed that chronic, high exposure to PO can induce tumors at the site of contact. Despite these characteristics, there is no evidence that typical environmental or occupational exposures to PO constitute a health risk for humans. The nongenotoxic effects of PO (glutath...     »
Zeitschriftentitel:
Crit Rev Toxicol
Jahr:
2009
Band / Volume:
39
Heft / Issue:
6
Seitenangaben Beitrag:
462-86
Sprache:
eng
Volltext / DOI:
doi:10.1080/10408440902837959
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19545197
Print-ISSN:
1040-8444
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
 BibTeX