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Titel:

Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy.

Dokumenttyp:
Journal Article; Review; Review
Autor(en):
Ahles, A; Engelhardt, S
Abstract:
Beta(1)- and beta(2)-adrenoceptors are crucial regulators of cardiovascular function. Agonists and antagonists at these receptor subtypes are cornerstones in the treatment of cardiovascular disease. In humans, both of the genes encoding the beta(1)- and beta(2)-adrenoceptors carry frequent polymorphisms resulting in different variants of the receptor proteins. Whether the polymorphic nature of the receptors causes the clinically observed differences with respect to the response of the patients t...     »
Zeitschriftentitel:
Trends Pharmacol Sci
Jahr:
2009
Band / Volume:
30
Heft / Issue:
4
Seitenangaben Beitrag:
188-93
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.tips.2009.02.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19272658
Print-ISSN:
0165-6147
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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