Login
- Document type:
- Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Haritoglou, I; Wolf, A; Maier, T; Haritoglou, C; Hein, R; Schaller, UC
- Title:
- Osteopontin and 'melanoma inhibitory activity': comparison of two serological tumor markers in metastatic uveal melanoma patients.
- Abstract:
- BACKGROUND: Evaluation of the protein osteopontin (OPN) as a potential new marker in comparison to melanoma inhibitory activity (MIA) for screening and detection of metastatic uveal melanoma. METHODS: Plasma levels of 32 patients with uveal melanoma were analyzed for OPN and MIA by enzyme-linked immunosorbent assay (ELISA). Fourteen of these patients had clinically detectable liver metastases. RESULTS: Median plasma concentration of OPN in patients with metastatic disease was 152.01 ng/ml compared to 47.39 ng/ml in patients without clinically detectable metastases (p < 0.001). The difference between the median MIA plasma levels in patients with (13.11 ng/ml) and patients without (5.64 ng/ml) metastatic disease was also statistically significant (p < 0.001). No correlation could be found between MIA or OPN levels and tumor height in patients without clinically detectable metastases. CONCLUSION: The proteins MIA and OPN seem to be promising tumor markers for the metastasis screening in patients with uveal melanoma.
- Journal title abbreviation:
- Ophthalmologica
- Year:
- 2009
- Journal volume:
- 223
- Journal issue:
- 4
- Pages contribution:
- 239-43
- Language:
- eng
- Fulltext / DOI:
- doi:10.1159/000206139
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/19270465
- Print-ISSN:
- 0030-3755
- TUM Institution:
- Klinik und Poliklinik für Dermatologie und Allergologie
BibTeX