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Titel:

Biophysical characterization of copolymer-protected gene vectors.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Autor(en):
Honig, D; DeRouchey, J; Jungmann, R; Koch, C; Plank, C; Rädler, JO
Abstract:
A copolymer-protected gene vector (COPROG) is a three-component gene delivery system consisting of a preformed DNA and branched polyethylenimine (bPEI) complex subsequently modified by the addition of a copolymer (P6YE5C) incorporating both poly(ethylene glycol) (PEG) and anionic peptides. Using fluorescence correlation spectroscopy (FCS) and atomic force microscopy (AFM), we characterized and compared the self-assembly of bPEI/DNA particles and COPROG complexes. In low salt buffer, both bPEI/DN...     »
Zeitschriftentitel:
Biomacromolecules
Jahr:
2010
Band / Volume:
11
Heft / Issue:
7
Seitenangaben Beitrag:
1802-9
Sprache:
eng
Volltext / DOI:
doi:10.1021/bm1002569
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20672861
Print-ISSN:
1525-7797
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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