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Title:

Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice.

Document type:
Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Laitinen, I; Saraste, A; Weidl, E; Poethko, T; Weber, AW; Nekolla, SG; Leppänen, P; Ylä-Herttuala, S; Hölzlwimmer, G; Walch, A; Esposito, I; Wester, HJ; Knuuti, J; Schwaiger, M
Abstract:
BACKGROUND: (18)F-Galacto-RGD is a positron emission tomography (PET) tracer binding to alpha(v)beta(3) integrin that is expressed by macrophages and endothelial cells in atherosclerotic lesions. Therefore, we evaluated (18)F-galacto-RGD for imaging vascular inflammation by studying its uptake into atherosclerotic lesions of hypercholesterolemic mice in comparison to deoxyglucose. METHODS AND RESULTS: Hypercholesterolemic LDLR(-/-)ApoB(100/100) mice on a Western diet and normally fed adult C57BL...     »
Journal title abbreviation:
Circ Cardiovasc Imaging
Year:
2009
Journal volume:
2
Journal issue:
4
Pages contribution:
331-8
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCIMAGING.108.846865
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19808614
Print-ISSN:
1941-9651
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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