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Titel:

Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schön, U; Diem, O; Leitner, L; Günzburg, WH; Mager, DL; Salmons, B; Leib-Mösch, C
Abstract:
The human genome contains more than half a million human endogenous retrovirus (HERV) long terminal repeats (LTRs) that can be regarded as mobile regulatory modules. Many of these HERV LTRs have been recruited during evolution as transcriptional control elements for cellular gene expression. We have cloned LTR sequences from two HERV families, HERV-H and HERV-L, differing widely in their activity and tissue specificity into a murine leukemia virus (MLV)-based promoter conversion vector (ProCon)....     »
Zeitschriftentitel:
J Virol
Jahr:
2009
Band / Volume:
83
Heft / Issue:
23
Seitenangaben Beitrag:
12643-50
Sprache:
eng
Volltext / DOI:
doi:10.1128/JVI.00858-09
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19741000
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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