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Title:

Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Krönig, H; Hofer, K; Conrad, H; Guilaume, P; Muller, J; Schiemann, M; Lennerz, V; Cosma, A; Peschel, C; Busch, DH; Romero, P; Bernhard, H
Abstract:
The cancer-testis antigen NY-ESO-1 has been targeted as a tumor-associated antigen by immunotherapeutical strategies, such as cancer vaccines. The prerequisite for a T-cell-based therapy is the induction of T cells capable of recognizing the NY-ESO-1-expressing tumor cells. In this study, we generated human T lymphocytes directed against the immunodominant NY-ESO-1(157-165) epitope known to be naturally presented with HLA-A*0201. We succeeded to isolate autorestricted and allorestricted T lympho...     »
Journal title abbreviation:
Int J Cancer
Year:
2009
Journal volume:
125
Journal issue:
3
Pages contribution:
649-55
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.24414
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19444908
Print-ISSN:
0020-7136
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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