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Titel:

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.

Dokumenttyp:
Journal Article; Review
Autor(en):
Ebbesen, P; Pettersen, EO; Gorr, TA; Jobst, G; Williams, K; Kieninger, J; Wenger, RH; Pastorekova, S; Dubois, L; Lambin, P; Wouters, BG; Van Den Beucken, T; Supuran, CT; Poellinger, L; Ratcliffe, P; Kanopka, A; Gorlach, A; Gasmann, M; Harris, AL; Maxwell, P; Scozzafava, A
Abstract:
Cancer cells in hypoxic areas of solid tumors are to a large extent protected against the action of radiation as well as many chemotherapeutic drugs. There are, however, two different aspects of the problem caused by tumor hypoxia when cancer therapy is concerned: One is due to the chemical reactions that molecular oxygen enters into therapeutically targeted cells. This results in a direct chemical protection against therapy by the hypoxic microenvironment, which has little to do with cellular b...     »
Zeitschriftentitel:
J Enzyme Inhib Med Chem
Jahr:
2009
Band / Volume:
24 Suppl 1
Seitenangaben Beitrag:
1-39
Sprache:
eng
Volltext / DOI:
doi:10.1080/14756360902784425
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19330638
Print-ISSN:
1475-6366
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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