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Document type:
Journal Article; Article 
Author(s):
Kofler, S; Shvets, N; Bigdeli, AK; König, MA; Kaczmarek, P; Deutsch, MA; Vogeser, M; Steinbeck, G; Reichart, B; Kaczmarek, I 
Title:
Proton pump inhibitors reduce mycophenolate exposure in heart transplant recipients-a prospective case-controlled study. 
Abstract:
This prospective study investigates the impact of proton pump inhibitors (PPI) on mycophenolic acid (MPA) pharmacokinetics in heart transplant recipients receiving mycophenolate mofetil (MMF) and tacrolimus. MPA plasma concentrations at baseline (C(0 h)), 30 min (C(0.5 h)), 1(C(1 h)) and 2 h (C(2 h)) were obtained by high-performance liquid chromatography (HPLC) in 22 patients treated with pantoprazole 40 mg and MMF 2000 mg. Measurements were repeated 1 month after pantoprazole withdrawal. A fou...    »
 
Journal title abbreviation:
Am J Transplant 
Year:
2009 
Journal volume:
Journal issue:
Pages contribution:
1650-6 
Language:
eng 
Print-ISSN:
1600-6135 
TUM Institution:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)