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Title:

Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kastenmuller, W; Gasteiger, G; Stross, L; Busch, DH; Drexler, I
Abstract:
A major problem of current vaccines is storage stability, often requiring strict maintenance of cold chains. In the course of the eradication of smallpox, a freeze-dried vaccinia virus (Dryvax), which proved to be very stable, was used to overcome this limitation. However, Dryvax needs to be reconstituted before usage and is administered using a bifurcated needle, procedures that pose a number of additional health risks. We report in this study that a stable, lyophilized, modified vaccinia virus...     »
Journal title abbreviation:
J Immunol
Year:
2009
Journal volume:
182
Journal issue:
5
Pages contribution:
2573-7
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.0803871
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19234150
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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