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Title:

Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kohlhof, H; Hampel, F; Hoffmann, R; Burtscher, H; Weidle, UH; Hölzel, M; Eick, D; Zimber-Strobl, U; Strobl, LJ
Abstract:
The canonical mode of transcriptional activation by both the Epstein-Barr viral protein, Epstein-Barr virus-encoded nuclear antigen 2 (EBNA2), and an activated Notch receptor (Notch-IC) requires their recruitment to RBPJ, suggesting that EBNA2 uses the Notch pathway to achieve B-cell immortalization. To gain further insight into the biologic equivalence between Notch-IC and EBNA2, we performed a genome-wide expression analysis, revealing that Notch-IC and EBNA2 exhibit profound differences in th...     »
Journal title abbreviation:
Blood
Year:
2009
Journal volume:
113
Journal issue:
22
Pages contribution:
5506-15
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2008-11-190090
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19339697
Print-ISSN:
0006-4971
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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