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Title:

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Abdul-Sater, AA; Koo, E; Häcker, G; Ojcius, DM
Abstract:
Inflammasomes have been extensively characterized in monocytes and macrophages, but not in epithelial cells, which are the preferred host cells for many pathogens. Here we show that cervical epithelial cells express a functional inflammasome. Infection of the cells by Chlamydia trachomatis leads to activation of caspase-1, through a process requiring the NOD-like receptor family member NLRP3 and the inflammasome adaptor protein ASC. Secretion of newly synthesized virulence proteins from the chla...     »
Journal title abbreviation:
J Biol Chem
Year:
2009
Journal volume:
284
Journal issue:
39
Pages contribution:
26789-96
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M109.026823
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19648107
Print-ISSN:
0021-9258
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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