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Title:

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Enard, W; Gehre, S; Hammerschmidt, K; Hölter, SM; Blass, T; Somel, M; Brückner, MK; Schreiweis, C; Winter, C; Sohr, R; Becker, L; Wiebe, V; Nickel, B; Giger, T; Müller, U; Groszer, M; Adler, T; Aguilar, A; Bolle, I; Calzada-Wack, J; Dalke, C; Ehrhardt, N; Favor, J; Fuchs, H; Gailus-Durner, V; Hans, W; Hölzlwimmer, G; Javaheri, A; Kalaydjiev, S; Kallnik, M; Kling, E; Kunder, S; Mossbrugger, I; Naton, B; Racz, I; Rathkolb, B; Rozman, J; Schrewe, A; Busch, DH; Graw, J; Ivandic, B; Klingenspor, M; K...     »
Abstract:
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene of mice. Although these mice are generally healthy, they have qualitatively different ultrasonic vocalizations, decreased exploratory behavior and decreased dopamine concentrations in the brain suggesting that the humanized Foxp2 allele a...     »
Journal title abbreviation:
Cell
Year:
2009
Journal volume:
137
Journal issue:
5
Pages contribution:
961-71
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2009.03.041
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19490899
Print-ISSN:
0092-8674
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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