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Titel:

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Abdul-Sater, AA; Koo, E; Häcker, G; Ojcius, DM
Abstract:
Inflammasomes have been extensively characterized in monocytes and macrophages, but not in epithelial cells, which are the preferred host cells for many pathogens. Here we show that cervical epithelial cells express a functional inflammasome. Infection of the cells by Chlamydia trachomatis leads to activation of caspase-1, through a process requiring the NOD-like receptor family member NLRP3 and the inflammasome adaptor protein ASC. Secretion of newly synthesized virulence proteins from the chla...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2009
Band / Volume:
284
Heft / Issue:
39
Seitenangaben Beitrag:
26789-96
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M109.026823
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19648107
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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