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Title:

Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity.

Document type:
Journal Article
Author(s):
Peiser, M; Koeck, J; Kirschning, CJ; Wittig, B; Wanner, R
Abstract:
In epidermal Langerhans cells (LCs), the expression pattern and the functions of TLRs have been poorly characterized. By using mAb, we show that LCs from human skin express TLR1, -2, -5, -6, and -9, the cognate receptors for detection of specific bacteria-derived molecules. As compared with other TLR agonists, LCs acquired a more matured phenotype when activated by specific bacterial or synthetic TLR2 agonists. In addition, monocyte-derived Langerin(+)/CD1c(+)LCs (CD1c(+)MoLCs) secreted higher a...     »
Journal title abbreviation:
J Leukoc Biol
Year:
2008
Journal volume:
83
Journal issue:
5
Pages contribution:
1118-27
Language:
eng
Fulltext / DOI:
doi:10.1189/jlb.0807567
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18252867
Print-ISSN:
0741-5400
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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