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Title:

Mast cell-derived proteases control allergic inflammation through cleavage of IgE.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rauter, I; Krauth, MT; Westritschnig, K; Horak, F; Flicker, S; Gieras, A; Repa, A; Balic, N; Spitzauer, S; Huss-Marp, J; Brockow, K; Darsow, U; Behrendt, H; Ring, J; Kricek, F; Valent, P; Valenta, R
Abstract:
BACKGROUND: Cross-linking of mast cell-bound IgE releases proinflammatory mediators, cytokines, and proteolytic enzymes and is a key event in allergic inflammation. OBJECTIVE: We sought to study the effect of proteases released on effector cell activation on receptor-bound IgE and their possible role in the regulation of allergic inflammation. METHODS: Using molar ratios of purified recombinant tryptase and human IgE, we studied whether tryptase can cleave IgE. Similar experiments were performed...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2008
Journal volume:
121
Journal issue:
1
Pages contribution:
197-202
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2007.08.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17904627
Print-ISSN:
0091-6749
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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