Radical fluoroarylation in radiochemical synthesis

Titel:: Radical fluoroarylation in radiochemical synthesis
Dokumenttyp:: Article
Autor(en):: Hultsch, C; Blank, O; Wester, HJ; Heinrich, MR
Abstract:: In this study, we report on the radical [F-18]fluoroarylation of different olefins using 4-[F-18]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[F-18]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of F-18-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30-45% overall radiochemical yield starting from [F-18]fluoride. (C) 2008 Elsevier Ltd. All rights reserved.
Zeitschriftentitel:: Tetrahedron Lett
Jahr:: 2008
Band / Volume:: 49
Heft / Issue:: 11
Seitenangaben Beitrag:: 1881-1883
Sprache:: eng
Print-ISSN:: 0040-4039
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin
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