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- Dokumenttyp:
- Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Meining, A; Frimberger, E; Becker, V; von Delius, S; von Weyhern, CH; Schmid, RM; Prinz, C
- Titel:
- Detection of cholangiocarcinoma in vivo using miniprobe-based confocal fluorescence microscopy.
- Abstract:
- BACKGROUND & AIMS: The preoperative diagnosis of cholangiocarcinoma is associated with a low sensitivity. To overcome this limitation, a new imaging modality was evaluated to detect neoplasia in vivo in the biliary tract. METHODS: Fourteen patients with biliary strictures were examined. Mucosal imaging was performed with a miniaturized confocal laser scanning miniprobe introduced via the accessory channel of a cholangioscope. Thereafter, targeted biopsy specimens were taken from the same regions. RESULTS: All strictures could be reached. Presence of irregular vessels use confocal laser microscopy enabled prediction of neoplasia with an accuracy rate of 86%, sensitivity of 83%, and specificity of 88%. The respective numbers for standard histopathology were 79%, 50%, and 100%. The mean signal-to-noise-ratio of laser microscopic images acquired from malignant strictures differed significantly from those of benign origin (1.8 +/- 0.8 vs 2.6 +/- 1.0; P = .005). CONCLUSIONS: Miniprobe-based confocal laser scanning microscopy considerably increases sensitivity for the detection of biliary neoplasia and therefore represents a promising diagnostic approach.
- Zeitschriftentitel:
- Clin Gastroenterol Hepatol
- Jahr:
- 2008
- Band / Volume:
- 6
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 1057-60
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.cgh.2008.04.014
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/18639496
- Print-ISSN:
- 1542-3565
- TUM Einrichtung:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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