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Title:

Electrophoretic analysis of the mitochondrial outer membrane rupture induced by permeability transition.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zischka, H; Larochette, N; Hoffmann, F; Hamöller, D; Jägemann, N; Lichtmannegger, J; Jennen, L; Müller-Höcker, J; Roggel, F; Göttlicher, M; Vollmar, AM; Kroemer, G
Abstract:
A pathological increase of the permeability of the mitochondrial membranes may culminate in the irreversible rupture of the mitochondrial outer membrane. Such a permeability transition is lethal because it results in the release of death-inducing molecules from mitochondria and/or metabolic failure. Current methods to assess this outer membrane damage are mostly indirect or scarcely representative of the overall mitochondrial population. Here we present an analytical and preparative approach usi...     »
Journal title abbreviation:
Anal Chem
Year:
2008
Journal volume:
80
Journal issue:
13
Pages contribution:
5051-8
Language:
eng
Fulltext / DOI:
doi:10.1021/ac800173r
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18510346
Print-ISSN:
0003-2700
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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