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Titel:

Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Caetano, FA; Lopes, MH; Hajj, GN; Machado, CF; Pinto Arantes, C; Magalhães, AC; Vieira, Mde P; Américo, TA; Massensini, AR; Priola, SA; Vorberg, I; Gomez, MV; Linden, R; Prado, VF; Martins, VR; Prado, MA
Abstract:
The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2 signaling by interacting with the cellular prion (PrP(C)) at the cell surface, resulting in neuroprotection and increased neuritogenesis. Here, we investigated whether STI1 triggers PrP(C) trafficking and tested whether this process controls PrP(C)-dependent signaling. We found that STI1, but not a STI1 mutant unable to bind PrP(C), induced PrP(C) endocytosis. STI1-induced signaling did not occur in cells devo...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2008
Band / Volume:
28
Heft / Issue:
26
Seitenangaben Beitrag:
6691-702
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.1701-08.2008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18579743
Print-ISSN:
0270-6474
TUM Einrichtung:
Institut für Virologie
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