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Title:

Tamoxifen-inducible gene deletion in the cardiac conduction system.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hoesl, E; Stieber, J; Herrmann, S; Feil, S; Tybl, E; Hofmann, F; Feil, R; Ludwig, A
Abstract:
Temporally controlled gene deletion provides a powerful technique for examination of gene function in vivo. To permit use of this technology in the study of cardiac pacemaking, we attempted to generate a mouse line expressing an inducible Cre recombinase selectively in cardiac pacemaker cells. The tamoxifen-inducible CreER(T2) construct was 'knocked in' into the pacemaker channel HCN4 locus. In the absence of inducing agent, recombination was undetectable in HCN4-KiT mice. After injection of tam...     »
Journal title abbreviation:
J Mol Cell Cardiol
Year:
2008
Journal volume:
45
Journal issue:
1
Pages contribution:
62-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.yjmcc.2008.04.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18538341
Print-ISSN:
0022-2828
TUM Institution:
Institut für Pharmakologie und Toxikologie
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