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Title:

Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
El-Gogo, S; Staib, C; Lasarte, JJ; Sutter, G; Adler, H
Abstract:
BACKGROUND: Efficient vaccines against hepatitis C virus (HCV) infection are urgently needed. Vaccine development has been hampered by the lack of suitable small animal models to reliably test the protective capacity of immmunization. METHODS: We used recombinant murine gammaherpesvirus 68 (MHV-68) as a novel challenge virus in mice and tested the efficacy of heterologous candidate human vaccines based on modified vaccinia virus Ankara or adenovirus, both delivering HCV non-structural NS3 or cor...     »
Journal title abbreviation:
J Gene Med
Year:
2008
Journal volume:
10
Journal issue:
2
Pages contribution:
177-86
Language:
eng
Fulltext / DOI:
doi:10.1002/jgm.1144
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18076128
Print-ISSN:
1099-498X
TUM Institution:
Institut für Virologie
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