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Titel:

The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Mamani-Matsuda, M; Cosma, A; Weller, S; Faili, A; Staib, C; Garcon, L; Hermine, O; Beyne-Rauzy, O; Fieschi, C; Pers, JO; Arakelyan, N; Varet, B; Sauvanet, A; Berger, A; Paye, F; Andrieu, JM; MICHEL, M; Godeau, B; Buffet, P; Reynaud, CA; Weill, JC
Abstract:
The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We report that, whereas blood and spleen compartments present similar frequencies of IgG(+) cells, antismallpox memory B cells are specifically enriched in the spleen where they accou...     »
Zeitschriftentitel:
Blood
Jahr:
2008
Band / Volume:
111
Heft / Issue:
9
Seitenangaben Beitrag:
4653-9
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2007-11-123844
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18316630
Print-ISSN:
0006-4971
TUM Einrichtung:
Institut für Virologie
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