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Title:

Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zimmermann, S; Kiefer, F; Prudenziati, M; Spiller, C; Hansen, J; Floss, T; Wurst, W; Minucci, S; Göttlicher, M
Abstract:
Histone deacetylases (HDAC) reverse the acetylation of histone and nonhistone proteins and thereby modulate chromatin structure and function of nonhistone proteins. Many tumor cell lines and experimental tumors respond to HDAC inhibition. To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. These mice express a catalytically inactive fusion protein of the NH(2)-terminal part of HDAC2 a...     »
Journal title abbreviation:
Cancer Res
Year:
2007
Journal volume:
67
Journal issue:
19
Pages contribution:
9047-54
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-07-0312
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17909008
Print-ISSN:
0008-5472
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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