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Title:

Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer.

Document type:
Journal Article; Article
Author(s):
Walch, A; Seidl, S; Hermannstädter, C; Rauser, S; Deplazes, J; Langer, R; von Weyhern, CH; Sarbia, M; Busch, R; Feith, M; Gillen, S; Höfler, H; Luber, B
Abstract:
Rho GTPases are a family of major regulators of E-cadherin-mediated cell adhesion that are implicated in the carcinogenic process by deregulated expression of the family members itself or of upstream modulators or downstream effectors. Combined investigation of the Rho GTPase Rac1, the effector protein IQGAP1 and the activator Tiam1 in relation to expression or mutation of E-cadherin in gastric adenocarcinomas has not been reported. The aim of the study was to determine the expression and progno...     »
Journal title abbreviation:
Mod Pathol
Year:
2008
Journal volume:
21
Journal issue:
5
Pages contribution:
544-52
Language:
eng
Fulltext / DOI:
doi:10.1038/modpathol.2008.3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18246045
Print-ISSN:
0893-3952
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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