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Titel:

Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Urbonaviciute, V; Fürnrohr, BG; Meister, S; Munoz, L; Heyder, P; De Marchis, F; Bianchi, ME; Kirschning, C; Wagner, H; Manfredi, AA; Kalden, JR; Schett, G; Rovere-Querini, P; Herrmann, M; Voll, RE
Abstract:
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance against these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis of apoptotic cells with consecutive release of nuclear antigens may contribute to the immune pathogenesis. The architectural chromosomal protein and proinflammatory mediator high mobility group box pr...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2008
Band / Volume:
205
Heft / Issue:
13
Seitenangaben Beitrag:
3007-18
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20081165
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19064698
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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