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Title:

Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.

Document type:
Journal Article
Author(s):
Helming, L; Tomasello, E; Kyriakides, TR; Martinez, FO; Takai, T; Gordon, S; Vivier, E
Abstract:
Multinucleated giant cells, formed by fusion of macrophages, are a hallmark of granulomatous inflammation. With a genetic approach, we show that signaling through the adaptor protein DAP12 (DNAX activating protein of 12 kD), its associated receptor triggering receptor expressed by myeloid cells 2 (TREM-2), and the downstream protein tyrosine kinase Syk is required for the cytokine-induced formation of giant cells and that overexpression of DAP12 potentiates macrophage fusion. We also present evi...     »
Journal title abbreviation:
Sci Signal
Year:
2008
Journal volume:
1
Journal issue:
43
Pages contribution:
ra11
Language:
eng
Fulltext / DOI:
doi:10.1126/scisignal.1159665
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18957693
Print-ISSN:
1945-0877
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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