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Title:

MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Cramer, JP; Lepenies, B; Kamena, F; Hölscher, C; Freudenberg, MA; Burchard, GD; Wagner, H; Kirschning, CJ; Liu, X; Seeberger, PH; Jacobs, T
Abstract:
Plasmodium falciparum GPI contributes to malaria pathology by inducing cytokine release. It has been shown to be recognized through TLR2 and to a lesser extent TLR4 in vitro. However, previous findings on the role of TLRs in parasite clearance or pathology in vivo are conflicting. Thus, we analyzed the impact of TLR-signalling on protection using the P. yoelii infection model. Deficiency of single TLRs as well as triple TLR2/4/9-deficiency had no impact on parasitaemia. In contrast, mice deficie...     »
Journal title abbreviation:
Microbes Infect
Year:
2008
Journal volume:
10
Journal issue:
12-13
Pages contribution:
1259-65
Language:
eng
Fulltext / DOI:
doi:10.1016/j.micinf.2008.07.024
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18692153
Print-ISSN:
1286-4579
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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