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Title:

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements.

Document type:
Journal Article
Author(s):
Agger, EM; Rosenkrands, I; Hansen, J; Brahimi, K; Vandahl, BS; Aagaard, C; Werninghaus, K; Kirschning, C; Lang, R; Christensen, D; Theisen, M; Follmann, F; Andersen, P
Abstract:
BACKGROUND: It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for adequate protection. Furthermore, for some diseases such as tuberculosis, a cellular response seems to be the sole effector mechanism required for protection. The development of new adjuvants capable of inducing highly complex immune responses with stron...     »
Journal title abbreviation:
PLoS ONE
Year:
2008
Journal volume:
3
Journal issue:
9
Pages contribution:
e3116
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0003116
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18776936
Print-ISSN:
1932-6203
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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