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Titel:

Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schuster, IG; Busch, DH; Eppinger, E; Kremmer, E; Milosevic, S; Hennard, C; Kuttler, C; Ellwart, JW; Frankenberger, B; Nössner, E; Salat, C; Bogner, C; Borkhardt, A; Kolb, HJ; Krackhardt, AM
Abstract:
Cell-based immunotherapy in settings of allogeneic stem cell transplantation or donor leukocyte infusion has curative potential, especially in hematologic malignancies. However, this approach is severely restricted due to graft-versus-host disease (GvHD). This limitation may be overcome if target antigens are molecularly defined and effector cells are specifically selected. We chose formin-related protein in leukocytes 1 (FMNL1) as a target antigen after intensive investigation of its expression...     »
Zeitschriftentitel:
Blood
Jahr:
2007
Band / Volume:
110
Heft / Issue:
8
Seitenangaben Beitrag:
2931-9
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2006-11-058750
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17626842
Print-ISSN:
0006-4971
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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